天然高分子材料明胶(Gelatin,GT)和人工合成高分子材料聚己内酯(Polycaprolactone,PCL),两者都具有良好的生物相容性和可降解性,已被应用于组织工程研究领域。然而,单一组分的GT和PCL材料存在诸多缺点。GT/PCL复合材料克服了单一组分支架存在的缺点,具有理化性能佳和组分优势互补等特点,可应用于构建组织工程器官和修复组织损伤。本文对GT/PCL纳米纤维电纺膜的特征及其在组织工程多个领域中的应用研究现状进行系统性回顾。

Natural polymer gelatin(GT)and synthetic polymeric materials polycaprolactone(PCL)have good biocompatibility and biodegradability,which could be used in tissue engineering.However,the disadvantages of simple component GT or PCL limits their application in tissue engineering research.GT/PCL composite scaffold overcomes the shortcomings of the simple component,and has better physical and chemical characteristics with the complementary advantages of both components,therefore has been widely used in the research of producing tissue-engineered organs and repairing tissue damages.In this paper,the characteristics of GT/PCL composite electrospun nanofibrous scaffold and its applications in many fields of tissue engineering were systematically reviewed.