组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2018, Vol. 14 ›› Issue (3): 159-161.doi: 10.3969/j.issn.1673-0364.2018.03.012

• 综述 • 上一篇    下一篇

明胶/聚己内酯纳米纤维电纺膜在组织工程中的应用进展

燕丽，郑蕊，沈征宇   

  1. 上海交通大学医学院附属第九人民医院皮肤科
  • 收稿日期:2018-04-17 发布日期:2020-07-23
  • 作者简介:沈征宇（E-mail：neuronszy@sina．com）。

Application Advances of Gelatin/Polycaprolactone Electrospun Nanofibrous Scaffold in Tissue Engineering

YAN Li,ZHENG Rui,SHEN Zhengyu   

  1. Department of Dermatology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
  • Received:2018-04-17 Published:2020-07-23
  • Contact: 2017年中华医学会-欧莱雅中国人健康皮肤/毛发研究项目(S2017140912)

摘要： 天然高分子材料明胶(Gelatin,GT)和人工合成高分子材料聚己内酯(Polycaprolactone,PCL),两者都具有良好的生物相容性和可降解性,已被应用于组织工程研究领域。然而,单一组分的GT和PCL材料存在诸多缺点。GT/PCL复合材料克服了单一组分支架存在的缺点,具有理化性能佳和组分优势互补等特点,可应用于构建组织工程器官和修复组织损伤。本文对GT/PCL纳米纤维电纺膜的特征及其在组织工程多个领域中的应用研究现状进行系统性回顾。

关键词: 明胶, 聚己内酯, 纳米纤维电纺膜, 组织工程

Abstract: Natural polymer gelatin(GT)and synthetic polymeric materials polycaprolactone(PCL)have good biocompatibility and biodegradability,which could be used in tissue engineering.However,the disadvantages of simple component GT or PCL limits their application in tissue engineering research.GT/PCL composite scaffold overcomes the shortcomings of the simple component,and has better physical and chemical characteristics with the complementary advantages of both components,therefore has been widely used in the research of producing tissue-engineered organs and repairing tissue damages.In this paper,the characteristics of GT/PCL composite electrospun nanofibrous scaffold and its applications in many fields of tissue engineering were systematically reviewed.

Key words: Gelatin, Polycaprolactone, Electrospun nanofibrous scaffold, Tissue engineering

中图分类号: