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上皮间质转化现象对瘢痕疙瘩临床治疗的意义

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  • 中国医学科学院北京协和医院整形美容外科

网络出版日期: 2020-07-23

The Significance of Epithelium-to-Mesenchymal Transition in Keloid Treatment

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Online published: 2020-07-23

摘要

瘢痕疙瘩是一种过度生长的、致密的纤维组织,常常超过伤口范围生长,并且凸出于周围正常的皮肤.上皮间质转化的过程是指上皮细胞丧失细胞极性和细胞间的连接,由成熟的上皮来源细胞转变为成熟的间质细胞的现象,上皮间质转化现象对瘢痕疙瘩的治疗具有一定的临床意义.

本文引用格式

张明子,王晓军 . 上皮间质转化现象对瘢痕疙瘩临床治疗的意义[J]. 组织工程与重建外科杂志, 2017 , 13(3) : 121 -122 . DOI: 10.3969/j.issn.1673-0364.2017.03.001

Abstract

Keloid scar is a fibrogenesis tumor-like disease featured by invasion to the surrounding skin. Epithelium-to-mesenchymal transition (EMT) is a process which leads to the loss of epithelial cell polarity and cell-cell adhesion. Through the process of EMT, epithelial cells acquire migratory and invasive behavior and are thus able to transform into mesenchymal cells. EMT has a high clinical significance towards keloid treatment.
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