瘢痕疙瘩是一种过度生长的、致密的纤维组织,常常超过伤口范围生长,并且凸出于周围正常的皮肤.上皮间质转化的过程是指上皮细胞丧失细胞极性和细胞间的连接,由成熟的上皮来源细胞转变为成熟的间质细胞的现象,上皮间质转化现象对瘢痕疙瘩的治疗具有一定的临床意义.

Keloid scar is a fibrogenesis tumor-like disease featured by invasion to the surrounding skin. Epithelium-to-mesenchymal transition (EMT) is a process which leads to the loss of epithelial cell polarity and cell-cell adhesion. Through the process of EMT, epithelial cells acquire migratory and invasive behavior and are thus able to transform into mesenchymal cells. EMT has a high clinical significance towards keloid treatment.