组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2017, Vol. 13 ›› Issue (3): 121-122.doi: 10.3969/j.issn.1673-0364.2017.03.001

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上皮间质转化现象对瘢痕疙瘩临床治疗的意义

张明子，王晓军   

  1. 中国医学科学院北京协和医院整形美容外科
  • 发布日期:2020-07-23

The Significance of Epithelium-to-Mesenchymal Transition in Keloid Treatment

ZHANG Mingzi,WANG Xiaojun   

  • Published:2020-07-23

摘要： 瘢痕疙瘩是一种过度生长的、致密的纤维组织,常常超过伤口范围生长,并且凸出于周围正常的皮肤.上皮间质转化的过程是指上皮细胞丧失细胞极性和细胞间的连接,由成熟的上皮来源细胞转变为成熟的间质细胞的现象,上皮间质转化现象对瘢痕疙瘩的治疗具有一定的临床意义.

关键词: 上皮间质转化, 瘢痕疙瘩, 治疗

Abstract: Keloid scar is a fibrogenesis tumor-like disease featured by invasion to the surrounding skin. Epithelium-to-mesenchymal transition (EMT) is a process which leads to the loss of epithelial cell polarity and cell-cell adhesion. Through the process of EMT, epithelial cells acquire migratory and invasive behavior and are thus able to transform into mesenchymal cells. EMT has a high clinical significance towards keloid treatment.

Key words: Epithelium-to-mesenchymal transition, Keloid, Treatment

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