目的 探讨口服普萘洛尔治疗腮腺区巨大婴幼儿血管瘤的远期疗效。方法 2009年3~10月,对11例腮腺区的巨大婴幼儿血管瘤患儿给予口服普萘洛尔治疗(2 mg/Kg·d)。患儿年龄到8~12个月时,停止用药并观察远期疗效。结果本组患儿随访至少5年,平均随访(69.5±4.8)个月。长期随访结果显示,10例患儿(90.9%)疗效明显,但其中6例存在少量瘤体和/或红斑残留及局部皮肤松弛等情况,需后续进一步治疗以改善外观;1例患儿(9.1%)疗效欠佳,瘤体和红斑明显残留。结论 普萘洛尔治疗腮腺区巨大婴幼儿血管瘤远期疗效欠佳,仍需采取手术和激光等其他治疗方式进一步改善外观。

Objective To evaluate the long-term efficacy of propranolol for giant parotid infantile hemangiomas. Method From March 2009 to October 2009, 11 cases of giant parotid hemangiomas were treated with propranolol orally (2 mg/Kg·d). When children aged 8-12 months, propranolol treatment was stopped and the long-term efficacy was observed. Results More than 5 years follow-up had been completed in each patient (mean 69.5 ±4.8 months). Excellent results were observed in 10 cases (90.9%). Among them, a little skin laxity and red spot were residual in 6 cases, and further therapy was necessary to improve appearance. One case (9.1%) still had significant lump and erythema at 5 years follow-up. Conclusion The long-term efficacy of propranolol in treating gaint parotid infantile hemangiomas is not good enough. Other therapy is still necessary for the residual mass and skin lesion.