组织工程与重建外科杂志 ›› 2015, Vol. 11 ›› Issue (4): 246-254.doi: 10.3969/j.issn.1673-0364.2015.04.006

• 论著 • 上一篇    下一篇

普萘洛尔治疗腮腺区巨大婴幼儿血管瘤远期疗效研究

金云波,常雷,邹运,吕东泽,仇雅璟,应涵汝,陈彬,马刚,陈辉,林晓曦   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 发布日期:2020-07-23

The Long-term Research of Propranolol Treatment for Giant Parotid Infantile Hemangomas

JIN Yunbo,CHANG Lei,ZOU Yun,LV Dongze,QIU Yajing,YING Hanru,CHEN Bin,MA Gang,CHEN Hui,LIN Xiaoxi   

  • Published:2020-07-23
  • Contact: 国家自然科学基金面上项目(81272127);上海市卫生系统重要疾病联合攻关重点项目(2013zyjb0014)

摘要: 目的 探讨口服普萘洛尔治疗腮腺区巨大婴幼儿血管瘤的远期疗效。方法 2009年3~10月,对11例腮腺区的巨大婴幼儿血管瘤患儿给予口服普萘洛尔治疗(2 mg/Kg·d)。患儿年龄到8~12个月时,停止用药并观察远期疗效。结果本组患儿随访至少5年,平均随访(69.5±4.8)个月。长期随访结果显示,10例患儿(90.9%)疗效明显,但其中6例存在少量瘤体和/或红斑残留及局部皮肤松弛等情况,需后续进一步治疗以改善外观;1例患儿(9.1%)疗效欠佳,瘤体和红斑明显残留。结论 普萘洛尔治疗腮腺区巨大婴幼儿血管瘤远期疗效欠佳,仍需采取手术和激光等其他治疗方式进一步改善外观。

关键词: 腮腺, 婴幼儿血管瘤, 普萘洛尔

Abstract: Objective To evaluate the long-term efficacy of propranolol for giant parotid infantile hemangiomas. Method From March 2009 to October 2009, 11 cases of giant parotid hemangiomas were treated with propranolol orally (2 mg/Kg·d). When children aged 8-12 months, propranolol treatment was stopped and the long-term efficacy was observed. Results More than 5 years follow-up had been completed in each patient (mean 69.5 ±4.8 months). Excellent results were observed in 10 cases (90.9%). Among them, a little skin laxity and red spot were residual in 6 cases, and further therapy was necessary to improve appearance. One case (9.1%) still had significant lump and erythema at 5 years follow-up. Conclusion The long-term efficacy of propranolol in treating gaint parotid infantile hemangiomas is not good enough. Other therapy is still necessary for the residual mass and skin lesion.

Key words: Parotid, Infantile hemangioma, Propranolol

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