组织工程与重建外科杂志

组织工程与重建外科杂志 >

2009 , Vol. 5 >Issue 1: 32 - 34

DOI: https://doi.org/10.3969/j.issn.1673-0364.2009.01.009

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去抗原异种松质骨材料的生物相容性研究

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  • 漯河医学高等专科学校第二附属医院骨五科

网络出版日期: 2020-07-23

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The Biocompatibility Study of Antigen-Extracted Xenogeneic Cancellous Bone Matrix

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  • Department of Orthopaedics;The Second Affiliated Hospital of Luohe Medical College;Luohe 462000;China.;

Online published: 2020-07-23

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摘要

目的研究去抗原异种松质骨支架材料的生物相容性,为其在骨缺损修复领域中的临床应用提供实验依据。方法对去抗原异种松质骨支架材料进行急性毒性实验、热源实验、溶血实验、凝血实验、兔肌肉内种植实验和兔桡骨骨缺损修复实验研究。结果去抗原异种松质骨支架材料无毒性、无热源性、不引起溶血和凝血反应,植入兔肌肉后逐渐发生生物降解并被纤维组织取代,兔骨缺损区植入后可被骨组织取代。结论去抗原异种松质骨支架材料具有良好的生物相容性,是理想的骨支架材料。

关键词： 骨修复材料; 去抗原异种松质骨; 生物相容性; 组织工程

本文引用格式

王德超，李奎，崔冰，宁宇，程峰 . 去抗原异种松质骨材料的生物相容性研究[J]. 组织工程与重建外科杂志, 2009 , 5(1) : 32 -34 . DOI: 10.3969/j.issn.1673-0364.2009.01.009

Abstract

Objective To study the biocompatibility of antigen-extracted xenogeneic cancellous bone matrix for the clinical use in the bone reconstruction field. Methods Acute toxicity test, pyrogen test, hemolysis test, hemopexis test, and long-term muscle and bone implant reaction were included in this study to evaluate the biocompatibility of antique-extrated xenogenetic cancellous bone matrix. Results All results indicated that the material had no toxicity, and it did not cause hemolysis and hemopexis. The material...

Key words： Bone repair material; Antigen-extracted xenogeneic cancellous bone matrix; Biocompatibility; Tissue engineering

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