组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2009, Vol. 5 ›› Issue (1): 32-34.doi: 10.3969/j.issn.1673-0364.2009.01.009

• 论著 • 上一篇    下一篇

去抗原异种松质骨材料的生物相容性研究

王德超，李奎，崔冰，宁宇，程峰   

  1. 漯河医学高等专科学校第二附属医院骨五科
  • 发布日期:2020-07-23

The Biocompatibility Study of Antigen-Extracted Xenogeneic Cancellous Bone Matrix

WANG Dechao,LI Kui,CUI Bing,NING Yu,CHENG Feng   

  1. Department of Orthopaedics;The Second Affiliated Hospital of Luohe Medical College;Luohe 462000;China.;
  • Published:2020-07-23

摘要： 目的研究去抗原异种松质骨支架材料的生物相容性,为其在骨缺损修复领域中的临床应用提供实验依据。方法对去抗原异种松质骨支架材料进行急性毒性实验、热源实验、溶血实验、凝血实验、兔肌肉内种植实验和兔桡骨骨缺损修复实验研究。结果去抗原异种松质骨支架材料无毒性、无热源性、不引起溶血和凝血反应,植入兔肌肉后逐渐发生生物降解并被纤维组织取代,兔骨缺损区植入后可被骨组织取代。结论去抗原异种松质骨支架材料具有良好的生物相容性,是理想的骨支架材料。

关键词: 骨修复材料, 去抗原异种松质骨, 生物相容性, 组织工程

Abstract: Objective To study the biocompatibility of antigen-extracted xenogeneic cancellous bone matrix for the clinical use in the bone reconstruction field. Methods Acute toxicity test, pyrogen test, hemolysis test, hemopexis test, and long-term muscle and bone implant reaction were included in this study to evaluate the biocompatibility of antique-extrated xenogenetic cancellous bone matrix. Results All results indicated that the material had no toxicity, and it did not cause hemolysis and hemopexis. The material...

Key words: Bone repair material, Antigen-extracted xenogeneic cancellous bone matrix, Biocompatibility, Tissue engineering

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