Abstract: 　Objective　To study the clinical efficacy and related mechanism of traditional Chinese medicine on wound repair after surgery of non-puerperal mastitis(NPM) using systematic review and meta-analysis. Methods　All of the clinical randomized controlled trials on traditional Chinese medicine combined with surgery in the treatment of NPM were searched from databases of CNKI, Wanfang, VIP, PubMed, Embase and Cochrane Library from the inception of the databases to March 2022. Literature reading, screening and information extraction were carried out, and the included literature was systematically evaluated. Revman 5.3 software was used for meta-analysis. Results　A total of 17 literatures were finally included in the systematic review and meta-analysis. The effective rate was reported in 15 literatures, the recurrence rate in half a year was reported in 5 literatures, the recurrence rate in one year was reported in 5 literatures and the mechanism of clinical efficacy was reported in 7 literatures. The results of meta-analysis showed that the effective rate of traditional Chinese medicine combined with surgery (observed group) was 94.12%, which was significantly higher than 73.39% of simple surgery (control group, P<0.01). The half year recurrence rate in the observed group was 12.00%, which was significantly lower than 42.26% in the control group(P<0.01). The one-year recurrence rate in the observed group was 5.65%, which was significantly lower than 22.52% in the control group(P<0.01). The intervention measures in the observation group can significantly reduce the level of CRP, IL-6, TNF-α, IgA and IgG  in peripheral blood of patients with non-puerperal mastitis. Conclusion　The effective rate and recurrence rate of traditional Chinese medicine combined with surgery in the treatment of NPM were better than that of simple therapy of surgery.

Key words: Non-puerperal mastitis, 　Traditional chinese medicine therapy, 　Meta-analysis, 　Wound repair