There are many bioactive substances in the ocean, and about 80% of the biological resources on the earth exist in

the ocean. It has great potential to develop drugs and materials from the ocean. Marine active substances mainly include biological information substances, physiological active substances, marine biotoxins and biological functional materials. In this paper,

research progress of marine active substances with research and development prospect in the field of bone tissue engineering was

briefly introduced.

Chitosan, 　Alginate, 　Shuck, 　Marine collagens, 　Bone tissue engineering, 　Bone regeneration scaffold,