Objective To explore the application of verteporfin polylactic acid （HA/VP-PLA） nanogel on full-thickness skin wounds in rats and compare its performance with existing products in terms of healing efficacy and scar reduction. Methods Fifty male rats were selected， and full-thickness skin defects were created on their backs. The wound margins were sutured and secured with sterile steel rings. According to different wound medication regimens， the rats were randomly assigned to five groups： hyaluronic acid gel group， blank control group， HA/VP-PLA nanogel group， Jinfuning group， and MEBO group. Wound healing was monitored， and tissue samples were collected on days 9 and 18 post-surgery for hematoxylin-eosin， Masson， and picrosirius red staining. Immunohistochemical analyses were conducted to measure the expression of α-SMA and CD31. Results The healing rates in the HA/VP-PLA nanogel， Jinfuning， and MEBO groups were significantly greater than those in the blank control group. HE staining revealed less inflammatory infiltration and quicker repair in these groups compared to the control. Masson staining indicated that the HA/VP-PLA nanogel group had  looser and less dense collagen fibers than those in the control group， with better-organized collagen compared to the Jinfuning and MEBO groups. The extent of fibrosis on the 18th day was markedly reduced in the HA/VP-PLA group compared to the blank and hyaluronic acid gel groups. Sirius red staining showed that the ratio of type Ⅰ to Ⅲ collagen was lowest in the HA/ VP-PLA group， showing significant differences with both the control and MEBO groups. On day 9， CD31 expression was highest in the HA/VP-PLA group， significantly differing from other groups. Similarly，α-SMA expression was lowest on days 9 and 18 in the HA/VP-PLA group， with significant differences noted against the blank control group and the Jinfuning group on day 18. Conclusion The HA/VP-PLA nanogel is effective in promoting wound epithelialization， comparable to the Jinfuning and MEBO groups， but superior in reducing tissue fibrosis and scar formation， which had clinical transformation and application prospects.

Verteporfin, Polylactic acid nanoparticles, Scarless wound healing