Abstract: Mesenchymal stem cells （MSCs） have been widely applied in cell therapy due to their multipotent differentiation capabilities， homing properties， and immunoregulatory functions. MSC membranes and their derivatives retain the membrane composition and biological characteristics of the source cells， and have gradually become a new focus of drug delivery research. MSC membranes can not only target diseased tissues but also modulate host immune responses through immunoregulatory molecules， thereby assisting in therapy. They demonstrate excellent targeting ability and biocompatibility in the treatment of diseases such as inflammation and tumors. However， the specific composition and corresponding functions of MSC membranes still require further investigation， and challenges remain in large-scale production and preservation for clinical applications. In this paper， the biological characteristics of MSC membranes and their applications in drug delivery and disease treatment were summarized， and the potential of engineering modifications to enhance targeting efficiency and therapeutic potential was discussed， providing a reference for the development of novel cell membrane therapies and carrier systems.

Key words: 　Mesenchymal stem cells, 　Cell membranes, 　Drug delivery, 　Nanoparticles