fect. Methods The clinical data of 15 patients with C5-C6 VLU from January 2023 to September 2024 were

retrospectively reviewed. The size of ulcers ranged from 1.5 cm×1.5 cm to 10 cm×20 cm， of which 13 cases were deep to the dermis-fat layer， and 2 cases had exposed bone and muscle tendon. Lower extremity Doppler ultrasound and antegrade lower extremity venography angiography were used to evaluate the vascular condition of the lower extremity before determining treatment scheme. The comprehensive treatment scheme includes the management of venous hypertension， debridement， platelet-rich plasma （PRP） injection， wound repair （free skin grafting or skin flap grafting）， postoperative wearing vein pressure stockings for varicose， and regular PRP injection for lesion site. The patients were followed up for 6 months to 1 year after discharge. Healing rate of ulcer， CIVIQ-10 score and clinical severity score of venous lesions were recorded at multiple points during treatment and follow up. Results The ulcers in this group healed completely within 4-6 weeks after surgery （healing rate was 100%）. At the end of follow-up period，14 patients had no ulcer recurrence and 1 patient had recurrence. All patients had elevated scores of CIVIQ-10 and reduced scores of VCSS. Conclusion A comprehensive treatment scheme combining accurate preoperative evaluation of lower limb vascular and wound， management of venous hypertension， repairing wound by debridement， PRP injection and surgery， postoperative wearing pressure stockings and regular PRP injections after being discharged from the hospital can effectively increase the healing rate of VLU， reduce the rate of recurrence， and significantly improve the patient's quality of life.

Venous leg ulcer, Platelet-rich plasma, Combined therapy, Wound repair