In recent years， the regulatory role of YAP signaling in cell growth， proliferation， apoptosis， and senescence

has become a research hotspot. Existing evidence suggests that YAP plays an important role in the development of various degenerative diseases， including osteoarthritis. YAP has a bidirectional regulatory effect on the proliferation， differentiation， and senescence of chondrocytes， mesenchymal stem cells， and macrophages in normal growth and development and pathological microenvironments. This bidirectional regulation depends on factors such as cell type and cell differentiation status. This article focuses on the biological structure and function of YAP， and reviews and prospects its regulatory mechanisms in cellular senescence in osteoarthritis

Yes-associated protein, Osteoarthritis, Cell senescence, Stem cells, Chondrocytes