Abstract: Recombinant humanized collagen is a full-length or partial amino acid sequence fragment encoded by a specific type of human collagen gene prepared by DNA recombination technology， or a combination containing human collagen functional fragments. Type Ⅲ collagen is a triple helix protein consisting of three identical α1 chains， encoded by the COL3A1 gene. Recombinant Ⅲ type humanized collagen（ RHC Ⅲ） has shown great potential for application in medical devices due to its good biological compatibility， cell adhesion， and functions of promoting new cell formation and cell growth. This article mainly focuses on the research and application status of RHC Ⅲ in the fields of tissue regeneration， medical cosmetology， immunotherapy， etc.， and makes prospects for the future development and application prospects of recombinant collagen.

Key words: Recombinant humanized collagen protein, &emsp, Type Ⅲ collagen, &emsp, Tissue regeneration, &emsp, Medical cosmetology, &emsp, Immunotherapy