Objective To compare the repair effect of pedicled perforator flap and traditional fascial pedicled flap in soft

tissue defects of limb wounds. Methods A total of 145 patients with soft tissue defects of limb wounds who underwent flap repair in the hospital were retrospectively analyzed between February 2022 and October 2024. According to different treatment methods， they were divided into group A （73 cases， repair with pedicled perforator flaps） and group B （72 cases， repair with traditional fascial pedicled flaps）. The flaps survival， wound healing， levels of growth factors in wound tissues， degree of wound pain， postoperative scars， recovery of limb function and the incidence of complications were compared between the two groups. Results At 7 days after surgery， difference in flaps survival between the two groups was not statistically significant （P>0.05）. At 1 week and 2 weeks after surgery， wound healing rates in group A were higher than those in group B （P<0.05）， but difference in wound healing rate between the two groups was not statistically significant at 3 weeks after surgery （P>0.05）. The wound healing time in group A was shorter than that in group B （P<0.05）. At 1 week after surgery， levels of PDGF， VEGF and EGF in group A were higher than those in group B （P<0.05）. At 1 week and 2 weeks after surgery， VAS scores in group A were lower than those in group B （P<0.05）， but difference in VAS score between the two groups was not statistically significant at 3 weeks after surgery （P>0.05）. At 6 months after surgery， scores of VSS （scar color， thickness， softness， vascular distribution） in group A were lower than those in group B （P<0.05）. At 3 months after  surgery， score of upper limb DASH in group A was lower than that in group B， while score of lower limb DASH was higher than that in group B （P<0.05）. At 6 months after surgery， difference in scores of upper and lower limbs between the two groups was not statistically significant （P>0.05）. The incidence of postoperative complications in group A was lower than that in group B （16.67% vs 5.48%，P<0.05）. Conclusion For the repair of soft tissue defects in limb wounds， compared with traditional fascial pedicled flap， pedicled perforator flap has more advantages in promoting early wound healing， increasing levels of growth factors， alleviating early pain， improving postoperative scars and early limb function， and reducing the incidence of complications

Limb wound, Soft tissue defect, Pedicled perforator flap, Fascial pedicled flap, Repair effect