Original article

Weighted Genes Co-Expression Network Analysis of M2 Macrophages Regulating Hypertrophic Scar F ormation

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  • Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China)

Received date: 2019-03-15

  Revised date: 2019-04-20

  Online published: 2019-06-20

Abstract

Objective To explore the specific mechanism of M2 macrophages and Th2 cytokines in the process of hypertrophic scar formation.Methods The weighted gene co-expression network analysis(WGCNA)was used to analysis the genome-wide expression data of mouse hypertrophic scar GSE26390,and the co-expression gene module and core regulatory genes highly correlated with M2 macrophage,Th2 cytokine and fibrosis were obtained.Results The following 8 genes were identified as core regulatory genes of M2 macrophages and Th2 type cytokines involved in the formation of hypertrophic scar:CLEC4A,CYBA,LOXL2,Hcvn1,NCKAP1L,PRRX2,LGALS9,CMTM3.Conclusion The above eight genes are involved in the regulation of immune response,extracellular matrix formation,tissue repair and other processes related to macrophage and T cells,and are potential new targets for prevention and treatment of hypertrophic scars.

Cite this article

WANG Zi,SUN Tingye,TAO Xiaoting,WANG Xin,ZHUANG Meiting,LI Haizhou,LI Qingfeng . Weighted Genes Co-Expression Network Analysis of M2 Macrophages Regulating Hypertrophic Scar F ormation[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019 , 15(3) : 146 -151 . DOI: 10.3969/j.issn.1673-0364.2019.03.005

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