Objective To explore the clinical effect of Concentrated Growth Factor(CGF)in treating Androgenetic Alopecia(AGA).Methods Twenty cases of AGA patients were treated with subcutaneous injection of CGF in alopecia area and were followed up for at least 12 weeks after treatment.The effectiveness were evaluated before and after treatment for 4,8,12 weeks.The efficacy of the treatment was comprehensively evaluated by digital photographs,Global Aesthetic Improvement Scale(GAIS)scale,trichoscopy images and the patient satisfaction questionnaire.The safety of the treatment was evaluated by observing the signs of infection,swelling or ulceration in the injection area.Results Gross photographs showed that the hair coverage increased significantly and the appearance of hair loss improved after the injection of CGF.The GAIS score suggested that CGF was effective for the management of AGA.The hair density and the ratio of terminal hair/vellus hair(T/V ratio)were increased showed by trichoscopy images.The patients'satisfaction rate was 85%.No side effects was observed during the follow-up period.Conclusion CGF is a safe and effective method for the treatment of androgenic alopecia.It is easier to produce and master and may be used as a novel therapy for the management of AGA.