Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma. Its high recurrence rate is a clinical challenge. The complete resection of the sarcoma with the maximum reservation of normal tissue is the key to the treatment. The three-dimensional pre-operative reconstruction technique has been applied into many kinds of tumor. It contributes greatly to operative planning and precising resection of tumor. In this paper, the treatment progress of DFSP and the application prospects of 3D pre-operative reconstruction technique in DFSP were discussed, providing a new idea for the precise treatment of DFSP.