Objective To explore the clinical effects of the split-thickness skin graft from scalp in wound repair. Methods From January 2006 to January 2016, 27 patients received wound repair by the split-thickness skin graft from scalp. All of the wounds were located in the extremities and trunk. The size of the wounds ranged from 5 cm×9 cm to 17 cm× 21 cm. The thickness of skin graft ranged from 0.30 mm to 0.4 mm. Results Most of the skin grafts survived very well. The skin graft started to contract 1 to 3 months after transplantation, and became flat again 6 months to 1 year after transplantation with good appearance. The donor site in scalp healed in 10 to 14 days, and the hair growth was normal without scar. Conclusion Split-thickness skin graft from scalp is a good choice for the wound repair, which avoids the permanent injury on donor site, and is worthy of clinic application.