Objective To explore effective perioperative nursing measures for minimally invasive laser pouch plasty. Methods From March 2014 to April 2016, 64 cases with eye bag were selected and randomly divided into experimental group (n=32) and control group (n=32). All patients were treated with super pulse CO2 laser method. The patients in control group received routine nursing care after operation, while the patients in experimental group received targeted systematic nursing based on the routine nursing. The satisfaction rate of the nursing and the complications of the two groups were compared. Results In the evaluation of nursing satisfaction, the satisfaction rate of the control group was only 81.25%, which was significantly lower than that of the experimental group (96.88%). The incidence rate of postoperative complications in the control group (28.13%) was significantly higher than in the experimental group (6.25%). Conclusion In the perioperative period, targeted systematic nursing is very important to improve the treatment effect and the satisfaction of nursing work, and can reduce the incidence of postoperative complications, which is worthy of clinical application.