Nasolabial fold as a dividing line located between the zygomatic cheek and upper lip is one of the earliest signs of aging, which gradually deepened with the age. The treatment for nasolabial fold wrinkle is still a problem, which is difficult to conquer. People are more increasingly focused on how to apply the ideal technology to achieve the curative effect as long as possible and to reduce the recurrence as far as possible. In this paper, according to the latest literature available on the subject, the research progress on the treatment for nasolabial fold rejuvenation was reviewed.