Objective To evaluate the clinical outcomes and aesthetic results of immediate reconstruction of partial mastectomy defects by local skin flaps. Methods From July 2004 to January 2013, 9 patients with breast cancer of early stage underwent immediate reconstruction of partial mastectomy defects using lateral thoracodorsal fasciocutaneous flap (n=7) and thoracoepigastric flaps (n=2). Flap and donor site complications were evaluated. Information on aesthetic results was collected. Results The final cosmetic result was considered to be excellent in 8 patients and good in one patient. Limited flap necrosis occurred in one patient and was treated by a conservative approach. The one case of donor site infection was treated with oral antibiotics and achieved satisfactory results. Mean time of follow-up was 22 months, no local recurrences were observed. Conclusion Immediate repair of partial mastectomy defects with local skin flap results in a low risk of complications and excellent aesthetic outcomes. The technique facilitates the breast surgeon’s ability to accomplish a widely negative resection margin around tumor, which has the potential to achieve lower rates of local recurrence.