Review

GNAQ M utations in P ort-W ine S tains

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  • Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China.Corresponding author:LIN Xiaoxi E-mail:linxiaoxi@126.com).

Online published: 2020-07-23

Abstract

G-alpha-q (GNAQ) is the alpha subunit of the heterotrimeric GTP-binding proteins that mediates the regulators of several downstream signaling through coupling cell surface receptors. Recently, lesions within port-wine stains are found harbor mutations in GNAQ p.Arg183 and may at least associate with ERK (extracellular signal-regulated kinase) signaling pathways. In this paper, the mutations of GNAQ within port-wine stains and the multiple activated signaling targets downstream of mutant GNAQ, including MAPK, RGS5, PKC and YAP pathways were reviewed.

Cite this article

ZHU Jiafang,YUWenxin,MA Gang,LIN Xiaoxi . GNAQ M utations in P ort-W ine S tains[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2016 , 12(5) : 322 -324 . DOI: 10.3969/j.issn.1673-0364.a460

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