Objective To evaluate the clinical efficacy of hyaluronic filling in the treatment of facial wrinkles. Methods A total of 80 patients treated by hyaluronic filling for improving the facial wrinkles were enrolled in this study from January 2014 to June 2015. All patients were followed up for 6 months after the operation to analyze the improvement rate of facial wrinkles, adverse events and patients＇ satisfaction. Results For all 80 patients, the improvement rate of facial wrinkles was 93.8%, 90.0% and 86.3% at 1, 3 and 6 months after treatment. Mild adverse events were observed in the patients which was recovered after symptomatic treatment or automatically, and no serious adverse events were observed in these patients, including infection, tissue necrosis, granuloma, blood vessel embolism, etc. The overall satisfaction was 93.8%. Conclusion Hyaluronic filling can significantly improve the patient＇s facial wrinkles with long-lasting efficacy, low incidence of adverse reactions.