Objective To explore the diagnostic value of Skin Fibro Meter (SFM) in lymphedema diseases. Methods Sixteen cases of lymphedema patients and twenty cases of healthy people were included in this study as lymphedema group and control group respectively. With Skin Fibro Meter (Delfin company, Finland), SFM test was performed on bilateral limbs of lymphedema group and control group. In addition, bilateral tissue moisture content of each segment of patients in lym-phedema group was also measured. Results In lymphedema group, the average fibrosis value of healthy side was (0.07±0.01) and (0.13±0.05) of affected side (P<0.000 1). In lymphedema group, the average tissue moisture content was (4.47±2.09) in healthy side, and (6.4±3.76) in affected side (P=0.002). The moisture ratio was 43.2%and it presented a tendency of positive correlation with the D-value of fibrosis between the healthy side and affected side. The average fibrosis value was (0.06±0.02) in control group, and (0.13±0.05) in lymphedema group (P<0.000 1). Conclusion Skin Fibro Meter provides reliable basis for the diagnosis of lymphedema disease, its diagnostic value is worth further research and exploration.