Objective To explore the clinical effects of pedicle anterolateral thigh perforator flap for repairing soft tissue defects of perinescrotal. Methods From 2009 to 2013, the soft tissue defects of perinescrotal in 8 cases were pre-treated and then repaired with pedicle anterolateral thigh perforator flap. The flap size varied from 7.0 cm ×10.0 cm to 13.0 cm×21.0 cm. The secondary defect of donor site was directly sutured or repaired by split-skin grafts on opposite side. Results All of the 8 flaps survived successfully. The flaps were soft with no secondary scar contracture. All the patients were followed up for 6 months to 2 years. There were no recurrence of tumors in 2 years. The donor sites were well healed and no movement disorder of lower limb was observed. Conclusion It is an ideal election for repairing perineal defection by using pedicle anterolateral thigh perforator flap, and is worthy of clinical promotion.