Objective To investigate the clinical application of partial nevus excision combined with skin expansion for rapid treatment of large-sized external nevus. Methods Eleven patients with large-sized external nevus were performed two stage rapid treatment of partial nevus excision combined with skin expansion. The nevus sizes varied from 7.0 cm ×5.0 cm to 35.0 cm ×22.0 cm. All the patients were followed up for 12 to 24 months to investigate the clinical efficacy. Results Ten patients completed the whole course of treatment successfully and were satisfied with the results. The minimum duration was 4 weeks, the maximum duration was 9 weeks, and the mean duration was 6 weeks. The main complication was hematoma, occurred in 1 case. Conclusion Partial nevus excision combined with skin expansion is a good method for rapid treatment of large-sized external nevus.