Review

The Applications and Prospects of Bone Morphogenetic Proteins (BMPs) in Craniofacial Surgery

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  • Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine;

Online published: 2020-07-23

Abstract

The repair and reconstruction of facial bone deformities, bone defects, nonunion due to all causes are concerned in the craniofacial surgical work. Craniofacial bone are repaired and reconstructed mainly by means of osteotomy, bone-rearrangement combined with repair materials implantation. With the progress of cell biology and in-depth knowledge of the growth and development of craniofacial skeleton, a growing number of studies have shown that growth factors widely participate in the bone repair and reconstruction in the local regulation of bone tissue regeneration. The bone morphogenetic protein s (BMPs) is one of the focus. In this paper, the BMPs overview, the mechanism of promoting bone formation, animal experiments, preliminary clinical experience and many other aspects were reviewed to provide a theoretical basis for further research and the application of BMPs in the repair of craniofacial bone and reconstruction in the future.

Cite this article

LI Dong,WEI Min,XU Haisong . The Applications and Prospects of Bone Morphogenetic Proteins (BMPs) in Craniofacial Surgery[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2015 , 11(2) : 112 -115 . DOI: 10.3969/j.issn.1673-0364.2015.02.017

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