Objective To evaluate the effect of Mohs micrographic surgery in nasal basal cell carcinoma. Methods In 2014, 40 cases with nasal basal cell carcinoma were treated by Mohs micrographic surgery. The surgical effects were observed and compared with the traditional extended resection. Results The mean margin in this group using Mobs micrographic surgery was 1.8 mm. Operative incision of 39 cases were primary healing. Patients were satisfied with the appearance and surgical effects. All the patients were followed up for 6 to 24 months, no recurrence was observed. Conclusion Mobs micrographic surgery is more complete than traditional extended resection for treating nasal basal cell carcinoma. It can make more solutions to repair the lesions.