Objective To investigate the efficiency and safety of computer assistant designed implants (CADI) in the treatment of complex orbital abnormalities. Methods A retrospective study was applied on 106 cases suffered from complex orbital deformity and treated with CADI during Jan. 2009 to Dec. 2012. The 6 months ’ postoperative CT image was compared to the pre-operative design. The surface geometric deviation was analyzed to evaluate the accuracy of CADI in orbital reconstruction. And the complications were documented. Results Among 106 cases, the CT images of 105 cases were obtained. The average deviation of the 105 cases was (1.32 ±1.64) mm. In 85.72%cases, the deviation was less than 2 mm. Only in one case the implant was taken out due to severe frontal sinus infection. No other serious complications were observed. Conclusion Computer assistant designed implant is an efficient, accurate and safe solution to complex orbital deformities. It might be one of the first choices in the treatment of complex orbital deformities.