Objective To explore the application of computer aided design in facial fat autograft. Methods The technique of computer aided design was applied to determine the injection site and amount of autologous fat injection. According to preoperative planning, 6 patients with facial asymmetry were received facial fat autograft. Results All patients suffering from facial asymmetry were all satisfied with the effective results and the facial asymmetry deformity was corrected obviously. Conclusion Computer aided design technology is a useful method in individual facial fat autograft.