Objective To explore the effect of modified transsection and longitudinal suture in epicanthoplasty. Methods From March 2010 to April 2013, sixty-nine patients were operated with modified transsection and longitudinal suture in medial canthus to correct epicanthus. All the patients were followed up and the clinical efficacy was estimated. Results Fifty-three patients were followed up for 6 months to 18 months. The epicanthus was corrected completely or in major. No obvious scar and recurrence were observed. Conclusion Modified transsection and longitudinal suture is a simple and effective operative procedure in epicanthoplasty with lessened scar and low recurrence rate.