As the most common benign tumor of infancy, infantile hemangioma has its special evolution process. En-dotheile cells, as well as perictes play important roles in the occurrence, development and resolution of the infantile heman-gioma. In this article, by summarizing the source and diferentitation of perictes, and its relationship with endotheile cells, the mechanism of perictes in the fading of infantile hemangioma was reviewed.