Diabetic foot ulceration can be closely associated with the lesion of peripheral nerves, which are more vulnerable to oppression in anatomical narrow places. Peripheral neurolysis has become a treatment for diabetic peripheral neuropathy through releasing the compressed nerves. It can not only improve the symptoms caused by diabetic peripheral neuropathy, but also reduce the incidence of foot ulceration. In this article, the basic scientific and clinical researches that preventing foot ulceration by decompressing peripheral nerves of lower extremity in patients with diabetic neuropathy were reviewed.