Original article

Research Progress in Mechanisms of Macrophages Participating in Skeletal Muscle Regeneration

Expand
  • The 9th Hospital of Chinese People’s Liberation Army;Xijing Hospital,Fourth Military Medical University

Online published: 2020-07-23

Abstract

In recent years, many researches have demonstrated that macrophages play a vital role in organ or tissue regeneration. Macrophages are necessary for skeletal muscle regeneration after injury. The recruitment of circulating mono-cytes/macrophages was mediated through myogenic cells and muscle resident macrophages. Macrophages are involved in both phases of skeletal muscle regeneration: first, swallowing necrotic myo-fibers, then the phenotype of macrophages switched from pro-inflammatory to anti-inflammatory. Second, factors secreted by anti-inflammatory macrophages improved the differentiation of myogenic cells and resulted in regeneration of skeletal muscle.

Cite this article

QIAO Juan,HAO Xiaoyan,GUO Shuzhong . Research Progress in Mechanisms of Macrophages Participating in Skeletal Muscle Regeneration[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2013 , 9(5) : 292 -294 . DOI: 10.3969/j.issn.1673-0364.2013.05.015

Options
Outlines

/