Infantile hemangioma (IH) is the most common benign tumor in childhood, which has unique natural history with early proliferation and spontaneous involution courses. However its pathogenesis has not been elucidated, especially its specific biomarkers. In this paper, the research progress of this aspect was reviewed. Histologic biomarkers were consist of angiogenesis, placenta, apoptosis, hypoxia, inflammation, lymphatic, stem cell, pericyte and mast cell associated markers. Humoral biomarkers contained serum and urine markers, the former mainly had the cytokines such as estrogen and VEGF, the latter included bFGF and MMP-2. But so far there were not serum markers found to be closely related to the course of IH with strong sensitivity and specificity.