Objective To investigate the clinical efficacy and safety of 0.5% solution of topical timolol maleate for infantile hemangiomas.Methods A total of 25 infants with hemangiomas were treated by 0.5% solution of timolol maleate topically every eight hours in a thin layer(30 μL/cm2) as treatment group,while 17 cases of infants with hemangiomas were treated with normal saline topically every eight hours in a thin layer(30 μL/cm2) as control group.The parents are responsible for topical application of drug every day.The treatment lasted for six months and the patients were visited once a month.The changes of tumor size,texture and color were monitored and recorded at a regular interval.Symptomatic treatment was given timely for any acute signs and symptoms.Results In treatment group,the overall response of excellent was evaluated in 1 patient,good in 4 patients,moderate in 11 patients,poor in 9 patients,and the total effective rate was 64.00%.In control group,the overall response of excellent was evaluated in 0 patient,good in 0 patient,moderate in 3 patients,poor in 14 patients,and the effective rate was 17.65%.There was significant difference between the two groups(P<0.05).No obvious adverse reactions were observed.Conclusion Topical timolol maleate shows good therapeutic effect for superficial hemangiomas with good drug tolerability and minor adverse reaction.