Objective To evaluate the clinical results of Vacuum Sealing Drainage in repair of severe degloving injury of the hand.Methods Since 2008,10 patients with severe degloving injury of the hand(typeⅡ) were treated by full-thickness skin graft in palm and dorsum of the hand with VSD and fingers embedding in abdominal wall in first stage and skin transplantation in second stage with VSD.Results All skin graft in palm and dorsum of the hand survived well except 3 cases of local necrosis with secondary healing.Skin graft in fingers survived in 9 cases except 1 case of finger tip necrosis in three fingers.Conclusion Vacuum Sealing Drainage in the treatment of severe degloving injury of the hand works conveniently with short treatment cycle and less pain.All patients obtained satisfactory shape and function.