Objective To evaluate the clinical effects of the vacuum sealing drainage(VSD) in treating large defect of lower limb combing with infection.Methods Fourteen patients with large skin avulsion were treated by mesh skin grafting combining with VSD.Results The average duration of VSD is 8.5 days.13 patients survived all skin wound healing,and 1 patient skin graft survival of 95%.After dressing,the wound healing,limb motor function and appearance of a good recovery.Conclusion Mesh skin grafting with VSD for treatment of large defect with infection can provide better wound drainage,control infection and promote skin graft survival.