Objective To explore the clinical application of vacuum sealing drainage(VSD) in the patients of osteo-fascia compartment syndrome(OCS) with fasciectomy.Methods A total of 11 patients with OCS were treated by 18 fasciectomies with VSD.The area of wound was 26 cm × 10 cm-12 cm × 6 cm.Results Fasciectomy wounds of 18 patients were primarily closed and VSD without skin graft.Five cases were closed by one course of drainage,10 cases were closed by two courses of drainage,and the others were closed by three courses of drainage.The time of treatment ranged from 7 to 21 days,with 13 days in average.One case occurred infection but healed after debridement and dressing.After 3 to 6 follow-up,the wound were healed successful without any complications.Conclusion Fasciotomy wound can be closed successfully by vacuum sealing drainage.