Original article

An Animal Model of Simple Blast Injury on Abdominal Wall with Visceral Exposure on Rabbit

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  • 1 Department of Plastic Surgery,Xijing Hospital,Xi’an 710032,China;2 Fuzhou General Hospital,Fuzhou 350000,China;3 Department of Plastic Surgery,Chinese PLA General Hospital,Beijing 100853,China;4 Northwest Research Institute of Nuclear Industry,Xi’an 710004,China

Online published: 2020-07-23

Abstract

Objective To make an animal model of the simple abdominal wall blast injury with visceral exposure and to observe its long-term changes.Methods Twelve white rabbits of 8-10 weeks were randomly divided into two groups,and injured parts were marked under general anesthesia.A group:self-made enterocoelia protective device with 0.125 g TNT equivalent explosives ball on the site of injury;B Group:the same explosion source of injury without protective device.After injury,autopsy and pathologic examination were used to evaluate the animal model.Results Both groups of animal injury parts presented whole layer blast injury of abdominal wall was observed in both groups.The wound area of A group was(3.9+0.56) cm2,and B group was(3.83±0.49) cm2.There were no significant differences between the two groups(P>0.05).The survival time of A group was(141±87.78) h and B group was(3.67±2.25) h.There were significant differences between group A and Group B(P<0.05).The survival time of experimental group was longer in group A than group B.Autopsy and pathologic examination showed that the reasons for the early death in the group B was visceral injury and abdominal bleeding,while besides fiber adhesion,there was no obvious trauma on visceral in group A.Conclusion This experiment simulated the mechanism of abdominal wall blast injury.An animal model of simple abdominal wall blast injury with protective device can be used for long-term observation with effective protection.

Cite this article

WANG Hongkun,HAN Yan,WANG Zhanjiang,SHAO Jianchuan,YI Chenggang,XIA Wei,GUO Shuzhong,SHI Junli . An Animal Model of Simple Blast Injury on Abdominal Wall with Visceral Exposure on Rabbit[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2010 , 6(6) : 327 -338 . DOI: 10.3969/j.issn.1673-0364.2010.06.007

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