Journal of Tissue Engineering and Reconstructive Surgery >

2009 , Vol. 5 >Issue 2: 83 - 107

DOI: https://doi.org/10.3969/j.issn.1673-0364.2009.04.006

Original article

Exploratory Research for Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells on Femoral Head Osteonecrosis

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  • 1 Institute of Radiation and Irradiation Medicine;Academy of Military Medical Science;Beijing 100850;China;2 66400 Orthopaedic Hospital of PLA;Beijing 100143;

Online published: 2020-07-23

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Abstract

Objective To explore the clinical feasibility and therapeutic effect of mesenchymal stem cells modified by hepatocyte growth factor gene for treating femoral head osteonecrosis.Methods Autologous bone marrow mesenchymal stem cells(MSCs) from one patient with osteonecrosis of the femoral head in a stage of ARCO ⅢB were separated and expanded in vivo.Cells were modified by an adenoviral vector carrying human hepatocyte growth factor gene,and total cells of 1.0×107 were surgically implanted into the necrotic s...

Key words： Femoral head necrosis; Mesenchymal stem cells; Hepatocyte growth factor

Cite this article

LOU Xiao,GONG Ennian,SHANG Fengyuan,WEI Chenggang,SHI Zhichao,WANG Jinsong,WU Zuze,GUO Zikuan . Exploratory Research for Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells on Femoral Head Osteonecrosis[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009 , 5(2) : 83 -107 . DOI: 10.3969/j.issn.1673-0364.2009.04.006

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