Journal of Tissue Engineering and Reconstructive Surgery >

2009 , Vol. 5 >Issue 3: 143 - 147

DOI: https://doi.org/10.3969/j.issn.1673-0364.2009.06.007

Original article

Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats

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  • 1 Division of Neuroscience; Department of Histology and Embryology;Zhongshan School of Medicine;Sun Yat-sen University;Guangzhou 510080;China;2 Institute of Polymer Science;School of Chemistry and Chemical Engineering;Guangzhou 510275;China.;

Online published: 2020-07-23

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Abstract

Objective To explore the biocompatibility of the Poly(l-lactic acid)(PLLA) nano-fibrous scaffold with spinal cord tissue of rats.Methods PLLA three-dimensional(3D) scaffolds with macro/micro-pores and nano-fibrous structure were fabricated by phase separation from a ternary PLLA/dioxane/water system.MSCs-PLLA nano-fibrous scaffolds complex were constructed in vitro.Twelve SD rats were divided into two groups:control injured group and MSCs transplanted group.T10 spinal cord segment was exposed,and then trans...

Key words： PLLA; Nano-fibrous scaffold; Bone marrow mesenchymal stem cells; Spinal cord injury; Biocompatibility

Cite this article

ZHANG Yanqing,ZENG Yuanshan,HE Liumin,QUAN Daping,LI Yan . Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009 , 5(3) : 143 -147 . DOI: 10.3969/j.issn.1673-0364.2009.06.007

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