Abstract： For recycling the waste heat (121—146 ℃) produced by the chemical distillation process, a 150 kW organic working fluid radial turbine was designed by using R600a. Based on the preliminary structural parameters and performance parameters of the organic working fluid radial turbine by 1dimensional aerodynamic calculation, a computational fluid dynamics (CFD) numerical simulation of the organic working fluid radial turbine was conducted to investigate the overall performance and the flow field characteristics at design condition. The results indicated that under the conditions of a turbine inlet temperature of 110 ℃ and a turbine inlet pressure of 1.6 MPa, the organic working fluid radial turbine can produce an output power of 150.5 kW with a mass flow rate of 4.17 kg/s, a pressure ratio of 3.2 and an efficiency of 82.7%. The working fluid flows smoothly with a high efficiency at the design condition to meet the requirements of the organic working fluid expander of the power system.This paper can provide basic data for the organic working fluid radial turbine design by utilizing the waste heat from the chemical distillation process.