This paper, based on the target of applied talents training in independent colleges, the needs of modern society for applied talents, and the characteristics of the students and teachers in independent colleges, the paper analyzes the advantages and disadvantages of the traditional “knowledge-based” training mode. With the talent training philosophy of “people-orientation”, this paper puts forward the “three-transfer” mode to stimulate renovation, namely, transferring teachers’ dominant role in classroom teaching to a guiding role; transferring the students’ passive knowledge learning to autonomous cultivation of learning ability by revising the objective of personnel training plan; transferring the education administers’ duty of inspections and examinations into guidance and motivation. A lot of beneficial explorations have been done in terms of “role transferring” in the three key factors (teachers, students and education managers),these measures are proved to be practical and efficient by years of practice, and can provide a new way for applied talents training of the similar colleges.