The construction of new liberal arts aims to promote the research and innovation of humanities and social sciences through the integration of different disciplines. How should comparative literature and its journals constructed on a cross-disciplinary basis respond to this challenge and opportunity for academic development? The paper holds that comparative literature should summarize the existing cross-cultural and cross-disciplinary vision and methodology, grasp the scientific achievements in the new century and the characteristics of the highly globalized era, and learn actively from other social sciences and natural sciences, while adhering to the basic principles and core methods of comparative literature as one of the humanities. Professional academic journals should also follow the same practice to stick to academic ethics and carry out its academic purpose to function as a medium for the development of humanities scholarship in the new century.