Through the exploration of “Knowledge” in Transknowletology, this paper believes that the significance and value of translation activities of human being is the start point of Transknowletology. This newly-emerged theory further proposes specific criteria of translation criticism, emphasizing the uniqueness of local knowledge during translation process, the equal communication of both sides and the constructive influence on the target society. Such a critical perspective exhibits an overall consideration of human beings and will promote the integration of different research fields of previous translation studies.