Professor Yang Feng, the founder of Transknowletology, put forward the proposition that “The fusion of knowledge in science, sociology and humanities will solve the puzzle and problem of classification anxiety for the translation discipline for the time to come. Translatology armed with the knowledge of natural sciences, social sciences and humanities will inevitably become a meta discipline or supra subject”(Yang Feng 2021:2). Proceeding from the insightful statement, we can observe that Transknowletology intends to integrate the resources and refine its key concepts and reformulate its epistemic framework from the above three disciplines based on complex system to construct the meta-knowledge of translatology. Thus, Transknowletology as general translatology will necessarily touch upon the knowledge and ideas of translatology, philosophy, sociology, cognition, hermeneutics. Through analysis and synthesis, construction and refining, it will become a meta-discipline for translation studies embodying both the logical facts and ethic values.If it intends to reach such a goal, Transknowletology must include epistemic concepts, paradigms and epistemic reintegration and reclassification on its road map so as to reformulate its model. On the epistemic structure, it should proceed from the onotology, methodology and teleology of epistemology, attach importance to the dialectics of methodology, integrate East-West epistemology,reorganize the internal and external knowledge of translatology, give weight to humanistic, aesthetic and ethic knowledge. Thus formulated, it will depart from the binary separation of knowledge to the existential and life world experiences. Consequently, it will lessen the tensions between the scientific rationality and humanistic reason. Based on the “ method of harmonious balance of Transknowletology ” and the logic of dialogue, the newly formed branch of learning will perfect its methodology of restructuring its knowledge base and will eventually deal with the ultimate concern of “what is a translator” so as to actualize the “Epistemic Turn” in contemporary Translation Studies.