Traditional Chinese medicine (TCM) classics serve as the core carrier of TCM culture, and their translation pedagogy faces dual challenges of language conversion and knowledge reproduction. The Shanghai Key Course “TCM Classics: A Global View” is an interdisciplinary and integrated translation course designed under the theoretical guidance of the theory of Transknowletology. By analyzing various aspects of teaching practice, including curriculum design, faculty development, pedagogical innovation, evaluation systems, and the integration of teaching and research, this paper proposes that TCM classics translation teaching should transcend traditional language instruction. Instead, it ought to center on “knowledge reproduction” and adopt a framework of “truth, goodness, and beauty” for both instructional design and assessment. Leveraging AI-enabled smart teaching, the course offers innovative practical insights for the development of TCM foreign language disciplines and the cultivation of globally competent TCM professionals with cross-linguistic knowledge-building capabilities. The educational perspective of knowledge translation is also discussed.